Gack Lab

Publications

2019

Serman, T. and Gack, M.U. (2019). Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus. Viruses. doi: 10.3390/v11100970.

Riedl, W., Acharya D., Lee J., Liu, G., Serman, T., Chiang, C., Chan, Y.K., Diamond, M.S., Gack, M.U. (2019). Zika virus NS3 mimics a cellular 14-3-3 binding motif to antagonize RIG-I- and MDA5-mediated innate immunity. Cell Host & Microbe. doi: 10.1016/j.chom.2019.09.012

Liu X., Matrenec R., Gack MU., He B. (2019) Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy. Journal of Virology. doi: 10.1128/JVI.00497-19.

Lee, J.-H., Chiang, C. and Gack, M.U. (2019) Endogenous nucleic acid recognition by RIG-I-like receptors and cGAS. Journal of Interferon and Cytokine Research. 7 May 2019. doi: 10.1089/jir.2019.0015.

Serman, T. and Gack, M.U. (2019). FBXO38 Drives PD-1 to Destruction. Trends in Immunology2019 Feb 1; doi 10.1016/j.it.2018.12.005.

2018

Full, F., van Gent, M., Sparrer, K.M.J., Chiang, C., Zurenski, M.A., Scherer, M., Brockmeyer, N.H., Heinzerling, L., Stürzl, M., Korn, K., Stamminger, T., Ensser, A., and Gack, M.U. (2018). Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nature Microbiology, 2018 Nov 12; doi 10.1038/s41564-018-0285-5.

Sanchez, J.G., Sparrer, K.M.J., Chiang, C., Reis, R.A., Chiang, J.J., Zurenski, M.A., Wan, Y., Gack, M.U.* and Pornillos, O*. TRIM25 binds RNA to modulate cellular antiviral defense. Journal of Molecular Biology, 2018 Oct 17; doi: 10.1016.* Co-corresponding authors

Riedl, W. and Gack, M.U. (2018). Dusting for flu’s fingerprints. Nature Microbiology.2018 Oct 24; 3, 1196-1197.

van Gent, M., Sparrer, K.M.J and Gack, M.U. (2018). TRIM Proteins and Their Roles in Antiviral Host Defenses. Annual Review of Virology. 2018 Jun 27. doi: 10.1146.

van Gent, M. and Gack M.U. Viral Anti-CRISPR Tactics: No Success without Sacrifice. Immunity. 2018 Sep 18; 49(3): 391-393.

Moss, J., Gack, M.U., and Vaughan, M. (2018). ARD1/TRIM23. Encyclopedia of Signaling Molecules. 2018 Jul 20. doi: 10.1007/978-1-4614-6438-9_644-1.

Sparrer K.M.J & Gack M.U. TRIM Proteins: New Players in Virus-induced Autophagy. PLoS Pathogens, 2018 Feb 1;14(2):e1006787.

Chiang, J.J., Sparrer, K.M.J., van Gent, M., Lässig, C., Huang, T., Osterrieder, K., Hopfner, K. P., and Gack, M.U. (2018). Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity. Nature Immunology (2018) doi:10.1038/s41590-017-0005-y

D’Cruz AA, Kershaw NJ, Hayman TJ, Linossi EM, Chiang JJ, Wang MK, Dagley LF, Kolesnik TB, Zhang JG, Masters SL, Griffin MDW, Gack MU, Murphy JM, Nicola NA, Babon JJ, Nicholson SE. Identification of a second binding site on the TRIM25 B30.2 domain. The Biochemical Journal (2018) doi: 10.1042/BCJ20170427

2017

Chiang, C., Pauli, E.K., Biryukov, J., Feister, K.F., Meng, M., White, E.A., Münger, K., Howley, P.M, Meyers, C. and Gack, M.U. (2017). The human papillomavirus E6 oncoprotein targets USP15 and TRIM25 to suppress RIG-I-mediated innate immune signaling. Journal of Virology2017 Dec 20 doi: 10.1128/JVI.01737-17.

Sparrer KMJ,  Gableske S,  Zurenski MA,  Parker ZM,  Full F,  Baumgart GJ,  Kato J,  Pacheco-Rodriguez G,  Liang C,  Pornillos O,  Moss J,  Vaughan M, and Gack MU (2017). TRIM23 mediates virus-induced autophagy via activation of TBK1. Nature Microbiology 2017 Sep 4. doi: 10.1038/s41564-017-0017-2 PMID: 28871090.

Ma. Q., Ruan, H., Peng, L., Zhang, M., Gack, M.U., Yao, W.-D (2017). A Proteasome-independent Polyubiquitin Linkage Regulates Synapse Scaffolding, Efficacy, and Plasticity, Proc. Natl. Acad. Sci. U.S.A., 2017 Sep 25. pii: 201620153.

Gack, M.U. (2017). What viruses can teach us about the human immune system. PLoS Pathogens, Jul 13;13(7):e1006364. PMID: 28704547

Michiel van Gent & Michaela U. Gack (2017). Viral pathogenesis: Dengue virus takes on cGAS. Nature Microbiology 2017 Mar 27;2:17050. PMID: 28346454

2016

Cindy Chiang and Michaela U. Gack (2016). Post-translational Control of Intracellular Pathogen Sensing Pathways. Trends in Immunology, 2016 Nov 15. pii: S1471-4906(16)30179-X. PMID: 27863906

Michaela U. Gack* and Michael S. Diamond (2016). Innate immune escape by Dengue and West Nile viruses. Current Opinion in Virology, 2016 Oct 25;20:119-128. PMID: 27792906 *Corresponding author

Sanchez, J.G., Chiang, J.J., Sparrer K.M.J., Alam, S., Chi, M., Roganowicz, M., Sankaran, B., Gack, M.U.* and Pornillos, O.* (2016). Mechanism of TRIM25 catalytic activation in the RIG-I pathway. Cell Rep. 2016 Jul 13. pii: S2211-1247(16)30839-7. PMID: 27425606 *Co-corresponding authors

Chan YK, Gack MU. Viral evasion of intracellular DNA and RNA sensing. Nat Rev Microbiol. 2016 Jun;14(6):360-73. PMID: 27174148

Chan YK, Gack MU. A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity. Nat Immunol. 2016 Mar 21. PMID: 26998762

2015

Chiang J.J. and Gack M.U. (2015). Reading the fine print: sequence-specific activation of cGAS. Nature Immunology 2015 Sep 18; 16(10):1009-10. PMID: 26382862

Full F. and Gack, M.U. (2015). Delicate coordination of TRIM21’s dual activity in virus neutralization and signaling. Proceedings of the National Academies of Science 2015 Aug 11; 112(32):9797-8. PMID: 26240368

Sparrer, K.M. and Gack, M.U. (2015). Intracellular Detection of Viral Nucleic Acids. Current Opinion in Microbiology 2015 Mar 17;26:1-9. PMID: 25795286

Chan, Y.K. and Gack, M.U. (2015). RIG-I works double duty. Cell Host Microbe 2015 Mar 11;17(3):285-7. PMID: 25766287

Davis, M.E. and Gack, M.U. (2015). Ubiquitination in the Antiviral Immune Response. Virology 2015 Mar 6. PMID: 25753787

Chan, Y.K. and Gack, M.U. (2015). RIG-I-like receptor regulation in virus infection and immunity. Current Opinion in Virology. 2015 Jan 30;12C:7-14. PMID: 25644461

Carocci, M., Hinshaw, S.M., Rodgers, M.A., Villareal, V.A., Burri, D.J., Pilankatta, R., Maharaj, N.P., Gack, M.U., Stavale, E.J., Warfield, K.L., Yang, P.L. (2015). The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication. Antimicrob Agents Chemother. 2015 Jan;59(1):85-95. PMID: 25313218

2014

Chiang, J.J., Davis, M.E., and Gack, M.U. (2014). Regulation of RIG-I-like receptor signaling by host and viral proteins.Cytokine & Growth Factor Reviews 2014 Jun 21. PMID: 25023063

Verrier ER, Gack MU, Baumert TF. (2014) Cyclic guanosine monophophate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis. Hepatology 2014 Sep doi: 10.1002/hep.27187.

Davis, M.E., Wang, M.K., Rennick, L.J., Full, F., Mesman, A. W., Gringhuis, S. I., Geijtenbeek, T.B.H., Duprex, W.P., and Gack, M.U. (2014). Antagonism of the Phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5. Cell Host Microbe 16, 19-30. PMID: 25011105

Mesman, A. W., Zijlstra-Willems, E. M., Kaptein, T. M., Davis, M. E., Ludlow, M., Duprex, W.P., Gack, M.U., Gringhuis, S. I., and Geijtenbeek, T.B.H. (2014). Measles virus suppresses RIG-I like receptor activation in dendritic cells via DC-SIGN mediated inhibition of PP1 phosphatases. Cell Host Microbe 16, 31-42. PMID: 25011106

Full, F. and Gack, M.U. (2014). Prostaglandin E2: the villain in the host response to influenza virus. Immunity. 2014 Apr 17;40(4):453-4. PMID: 24745327

Gack, M.U. (2014). Mechanisms of RIG-I-like Receptor Activation and Manipulation by Viral Pathogens. J Virol. 2014 May;88(10):5213-6

Pauli, E.-K., Chan Y.K., Davis, M.E., Gableske, S., Wang, M.K., Feister, F.F., and Gack, M.U. (2014). The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25. Science Signaling 7, ra3 (2014)

2013

D’Cruz A.A., Kershaw N.J., Chiang J.J., Wang M.K., Nicola N.A., Babon J.J., Gack M.U., and Nicholson S.E. (2013). Crystal Structure of the TRIM25 B30.2 (PRYSPRY) domain: A Key Component of Antiviral Signaling. Biochem J. 2013 Dec 1;456(2):231-40

Wies, E., Wang, M.K., Maharaj, N.P., Chen, K., Zhou, S., Finberg, R. W., and Gack, M.U. (2013). Dephosphorylation of the RNA Sensors RIG-I and MDA5 by the Phosphatase PP1 Is Essential for Innate Immune Signaling. Immunity 2013 Mar 12. doi:10.1016/j.immuni.2012.11.018. PMID: 23499489

2012

Rajsbaum, R., Albrecht, R.A., Maharaj, N.P., Wang, M., Versteeg, G.A., Nistal-Villán, E., García-Sastre, A., and Gack, M.U. (2012). Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.  PLoS Pathogens 2012 Nov;8(11):e1003059. PMCID: PMC3510253

Maharaj, N.P., Wies, E., Stoll, A., and Gack, M.U. (2012). Conventional protein kinase C-α (PKC-α) and PKC-β negatively regulate RIG-I antiviral signal transduction. J Virol, 86(3):1358-71. PMCID: PMC3264329

2011

Gack M.U. TRIMming Flavivirus Infection (2011). Cell Host Microbe10:175-177. PMID: 21925103

Inn, K.S., Gack, M.U., Tokunaga, F., Shi, M., Wong, L.Y., Iwai, K., and Jung J.U. (2011). Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction. Molecular Cell 41(3):354-65.PMCID: PMC3070481

2010

Nistal-Villán, E., Gack, M.U., Martínez-Delgado, G., Maharaj, N.P., Inn, K., Yang, H., Wang, R., Aggarwal, A.K., Jung, J.U., García-Sastre, A. (2010). Negative Role of RIG-I Serine 8 Phosphorylation in the regulation of IFN-β Production. J Biol Chem.285(26):20252-61. PMCID: PMC2888438     

Gack, M.U., Nistal-Villán, E., Inn, K., Garcia-Sastre, A. & Jung, J.U. (2010). Phosphorylation-mediated negative regulation of RIG-I anti-viral activity. J Virol 84(7):3220-9. PMCID: PMC2838087

2009

Gack, M.U., Albrecht, R.A., Urano, T., Inn, K., Huang, I.C., Carnero, E., Farzan, M., Inoue, S., Jung, J.U. & Garcia-Sastre, A. (2009). Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 5:439-449. PMCID: PMC2737813

Myong, S., Cui, S., Cornish, P.V., Kirchhofer, A., Gack, M.U., Jung, J.U., Hopfner, P. & Ha, T. (2009). Cytosolic viral sensor RIG-I is a 5’-triphosphate-dependent translocase on double-stranded RNA.Science. 323(5917):1070-4.   PMID: 19119185

2008

Liang, C., Lee, J., Inn, K., Gack, M.U., Li, Q., Robert, E.A., Vergne, I., Deretic, V., Feng, P., Akazawa, C., & Jung, J.U. (2008). Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nature Cell Biology 10 (7), 776-87 PMCID: PMC2878716

Shin, Y.C., Joo, C.H., Gack, M.U., Lee, H.R., & Jung, J.U. (2008). Kaposi’s Sarcoma associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia inducible factor-1 alpha to induce vascular endothelial growth factor expression.Cancer Res. 68, 1751-1759. PMID: 18339855

Gack, M.U., Kirchhofer, A., Shin, Y.C., Inn, K., Liang, C., Cui, S., Myong, S., Ha, T.K., Hopfner, K.P., & Jung, J.U. (2008). Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated anti-viral signal transduction. Proc. Natl. Acad. Sci. U.S.A. 105(43):16743-8    PMCID: PMC2575490

2007

Joo, C.H., Shin, Y.C., Gack, M., Wu, L., Levy, D., & Jung, J.U. (2007). Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi’s sarcoma-associated herpesvirus viral IRF homolog vIRF3. J Virol 81, 8282-8292.  PMCID: PMC1951281

Gack, M.U., Shin, Y.C., Joo, C.H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., & Jung, J.U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920.  PMID: 17392790

2006 and before

Heck, E., Friedrich, U., Gack, M.U., Lengenfelder, D., Schmidt, M., Müller-Fleckenstein, I., Fleckenstein, B., Ensser, A., & Biesinger, B. (2006). Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.J Virol 80, 9934-9942.  PMCID: PMC1617286

Deichen, J.T., Prante, O., Gack, M., Schmiedehausen, K., Kuwert, T. (2003). Uptake of [18F] fluorodeoxyglucose in human monocyte-macrophages in vitro. Eur J Nucl Med Mol Imaging 30, 267-273.  PMID: 12552345